Research internships and scientific contributions in computational biology.
Computational modeling of the pancreatic tumor microenvironment combined with spatial tissue analysis.
Completed at the Toulouse Cancer Research Center (CRCT) in the NetB(IO)² team led by Vera Pancaldi, funded by Janssen. The project focused on pancreatic ductal adenocarcinoma (PDAC), studying how the tumor microenvironment adapts and resists treatment.
Large-scale annotation pipeline for non-coding 5'UTR variants in familial dyslipidemia genes.
Supervised by Antoine Rimbert at the Institut du Thorax (Inserm, Nantes). The project examined non-coding genetic variants in 5'UTR regions of genes involved in familial dyslipidemia — LDLR, APOB, PCSK9, APOE — regions often overlooked in standard analyses but critical for translational regulation.
Built a reproducible analysis chain combining ANNOVAR for VCF/BCF annotation and MORFEE for 5'UTR variant interpretation. Deployed as a Nextflow pipeline, it processed local cohorts and the UK Biobank (200,000+ individuals), detecting rare potentially pathogenic variants across the human genome.